Methylfolate and B Vitamins

Impryl is the antioxidant support with methylfolate to restore oxy-redox balance, energy production and cell viability for the health of the embryo and of the pregnancy and for a controlled ageing

Feeding and activating the endogenous antioxidant defenses

Impryl is the benchmark of the antioxidants support. According to the new strategy, instead of using antioxidant substances, that act only on a limited number of sensitive pathways and that may generate negative counter effects, Impryl leverage on the physiologic antioxidant system to achieve a better oxy-redox balance within the control of the natural cellular homeostasis. This approach is resulting in clinical improvements that appeared impossible by using traditional antioxidant molecules. In addition Impryl contains only substances normally present in the diet for a easy and safe use with no limits of duration.

Its formula contains all the substances required for the activation of antioxidant defenses in the absence of any substance with direct antioxidant activity. Moreover, it supplies the substances capable of compensating for the possible presence of the most common pathological variants of metabolic enzymes, in particular:

  • Folic acid in its methylated, active form (methylfolate) to compensate for a possible defect of the enzyme MTHFR (Methylene-Tetra-Hydro-Folate-Reductase)
  • Vitamin B12in its methylated, active form  (methylcobalamine) to compensate for a possible defect of the enzyme MTRR (5-methyltetrahydrofolate-homocysteine methyltransferase reductase)
  • Betaine (trimethyl glycine) to compensate for a possible defect of the enzyme CHDH (choline-dehydrogenase)
  • Cysteine donor (cystine) to compensate for a possible defect of the enzyme CBS (cystathionine beta synthetase)

Thus, Impryl provides the maximum possible support to the antioxidant defenses and will be active in all subjects independently of their genetic substrate.

Impryl is completely free from direct antioxidants and works by inducing the endogenous cellular antioxidant defenses that, subject to the regulation of cellular homeostasis, will act as far as necessary and useful to the cell.

Mechanism of action

Impryl is the first antioxidant dietary supplement based on a well defined mechanism of action: indirect antioxidant activity by means of the modulation of the enzyme CBS that regulates the synthesis of glutathione (GSH), the primary cellular antioxidant.

Impryl works by activating the primary biochemical cycle of our cells, the trans-methylations. This effect, besides globally improving the health of the cells, is mandatory to activate the physiologic antioxidant defenses, i.e the synthesis of GSH. The output of GSH and the antioxidant defenses are further supported by adding several specific substrates. The availability of methylfolate and methylcobalamine allow to compensate the most common defective variants of metabolic enzymes, namely MTHFR and MTRR.

Thus, the substances provided by Impryl allow the cells to activate the endogenous antioxidant defenses. The resulting antioxidant effect is comprehensive, i.e. affecting all the thousands metabolic reactions of concern, and associated to a beneficial influence on cell growth and differentiation. These effects occur within the control of the physiologic regulation of cellular activities and will never be excessive but will stop as soon the need will be satisfied, independently of the assumed amount.


Substances contained in Impryl:
L-cystine, betaine, niacin, chelated zinc, riboflavin, vitamin B6, folic acid in methylated form (methylfolate), vitamin B12 in methylated form (methylcobalamine).

Removing insulin resistance

Insulin is a pancreatic hormone that stimulates the uptake of glucose into the cells so to make it available for the production of energy within the cellular mitochondria. A defect of insulin activity causes accumulation of glucose in the blood (hyperglycaemia). Insulin resistance is a condition characterized by low sensitivity of the insulin receptors. When insulin resistance affects the whole body, including muclular tissues, it is responsible for Diabetes Mellitus type 2, when affecting mainly the ovarian follicles in fertile women it sustains the development of the Polycystic Ovary Syndrome (PCOS).

It has been now discovered that insulin resistance is actually a defensive mechanism aimed at avoiding cellular damage from excess of endogenous reactive oxygen species (ROS). Indeed, when too much of glucose and other energy substrates are processed the endogenous production of ROS may increase too much if mitochondrial GSH is not enough to neutralise. To avoid final damage the mitochondria signal to the cell to block the insulin receptor to avoid further entrance of glucose and further ROS generation. Impryl induces more abundant GSH into the cells and their mitochondria thus improving their ability to neutralise the endogenous ROS. As a consequence glucose enters again into the cells and  the insulin resistance is removed. This property of Impryl supplementation is the main reason for its positive effect on diabetes type 2 and on PCOS as well as in other conditions sustained by excess endogenous ROS such as neurodegenerations.


Supplement of health for all ages

Contributes to growth, to well being and to a controlled ageing – contains methylfolate and methylcobalamine

Support with Impryl


Impryl was conceived as a nutritional intervention to support the health of all and its use does not necessarily imply the presence of a condition to be corrected. In addition, the modern lifestyle and the increasing environmental pollution expose all of us to excessive oxidative assaults that should be duly balanced, possibly before the same hesitate in clinical damages.

Nevertheless, the metabolic normalization obtained with Impryl is particularly useful in case of malfunctions that have a clear metabolic basis and / or deficiency. For example, Impryl, assumed continuously or in cycles, is recommended for those who have high levels of circulating homocysteine and / or high risk of cardiovascular and neurodegenerative disease.

Thanks to the content in methylfolate and methylcobalamine, that compensate the common MTHFR and MTRR genetic polymorphism, Impryl may benefit everybody with no need for genetic testing.


The remarkable effectiveness of the antioxidant activation on the one hand and the respect for the metabolic physiology on the other, make Impryl the ideal support for reproduction. Gametogenesis is, among the physiological functions, the most sensitive to a perfect metabolic balance. This is currently defined as pre-conceptional support, i.e. a supplementation of both partners from at least three months before conception. The positive effects will concern not only the chances of conceiving but also the probability of having a serene pregnancy and a healthy baby. For comprehensive information see the preconception care advices from the World Health Organization (WHO).

Thereafter, once the pregnancy occurs, research has definitely confirmed the need for a pregnancy support with folic acid to prevent the Neural Tube Defects (NTDs) including spina bifida. More recent studies have demonstrated a similar protective effect on the onset of Autism Spectrum Disorders (ASD), which are a modern health alert, likely related to the environmental toxicity. Studies also indicate that a multivitamin support is preferable to folic acid alone. In addition, supplements providing folic acid in the form of methylfolate are better appropriate for subjects carryin a defective MTHFR gene. Final demonstrations will require many years but it is already clear that a supplementation covering all metabolic problems is preferable. Impryl is at present the most complete support for pregnancy.


Vasomotor symptoms, the so-called hot flashes with or without sweats, affect many women at peri-menopausal age and sometimes may persist in the long term with relevant consequences on the sleep pattern and on occupational activities. The mechanisms are not well clear but they certainly include some hyper-reactivity of the termo-regulation centre within the central nervous system (CNS) that reacts excessively to normal stimuli for temperature adjustments.

The concerned effector is an excitatory neurotransmitter called glutamate. It increases at menopausal age due to the fall of steroid hormones and peaks during the hormonal fluctuations typical of early menopause.  Also CNS homocysteine contributes by directly stimulating glutamate receptors and by inhibiting its re-adsorption at synaptic space, thus amplifying glutamate effect.

Impryl, due to its content in methylfolate and methylcobalamine, that are able to enter the CNS, favors the decrease of glutamate by inducing its consumption for the synthesis of glutathione and by activating the removal of homocysteine within the CNS. Treated women reported a very fast relief from symptoms, already after 3 days of treatment, and almost all of them were symptom free after one week.

In addition, circulating homocysteine is also an independent risk factor for osteoporosis. It is known that even the plain folic acid can improve bone density and reduce pathological fractures. Impryl, thanks to the all-round support to the folate pathway and to its suitability also to the carriers of the common genetic variants of the enzymes, qualifies as the better complete menopausal support so far available with relevant activity on both the symptoms and the complications.


The Polycystic Ovary Syndrome (PCOS) ia a very common condition characterised by ovarian cysts, hyperandrogenism, impaired glucose metabolism (sub-clinical diabetes) and ovulatory disturbances and may associate to sub-fertility. In many forms of PCOS the primary event is oxidative damage that, in susceptible women, triggers an insulin resistance and hyper-activation of the androgenic system.

A targeted antioxidant support with Impryl has the potential to block this process restoring a normal metabolic and endocrine function. In some cases Impryl has favoured a fast and complete regression of the syndrome.

It is to be noted that PCOS ladies are at a higher risk to carry a defective variant of the MTHFR gene and will benefit from the content in methylfolate of Impryl.


Impryl extended nutritional table
Nutritional profile For 100 g Per dose (1 tab) % NRV
Energetic content (kJ) 1119,39 KJ 8,45 kJ
Calories 267,54 kcal 2,02 kcal
Proteins 29,00 g 221,1 mg
Fats/Total lipids 3,78 g 30,91 mg
Saturated fats 0,46 g 10,23 mg
Monoinsaturated fats 0,53 g 16,61 mg
Polyinsaturated fats 2,58 g 2,31 mg
Cholesterol <0,001 mg <0,001 mg
Total carbohydrates 0 g 0 mg
Sugar 0 g 0 mg
Dietetic fibers 58,76 g 763,8/8 mg
Sodium 0,05 g 0,65 mg
Betaine 15,38 g 200 mg
L-cystine 15,38 g 200 mg
Zinc 0,76 g 10 100%
Niacin 1,23 g 16 mg 100%
Vitamin B6 107,7 mg 1,4 mg 100%
Riboflavin 107,7 mg 1,4 mg 100%
Folic acid (5MTHF – glucosamine) 30,77 mg 400 µg 200%
Vitamin B12 (methylcobalamin) 0,19 mg 2,5 µg 100%

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Improvement of gamete quality by stimulating and feedingthe endogenous antioxidant system: mechanisms, clinical results,insights on gene-environment interactions and the role of diet.

Authors: Maurizio Dattilo – D’Amato Giuseppe – Caroppo Ettore – Yves Ménézo